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Article

Harnessing Expressed Single Nucleotide Variation and Single Cell RNA Sequencing To Define Immune Cell Chimerism in the Rejecting Kidney Transplant.

Journal of the American Society of Nephrology : JASN - 1 Sept 2020

Malone Andrew F, Wu Haojia, Fronick Catrina, Fulton Robert, Gaut Joseph P, Humphreys Benjamin D

Abstract excerpt

BACKGROUND: In solid organ transplantation, donor-derived immune cells are assumed to decline with time after surgery. Whether donor leukocytes persist within kidney transplants or play any role in rejection is unknown, however, in part because of limited techniques for distinguishing recipient from donor cells. METHODS: Whole-exome sequencing of donor and recipient DNA and single-cell RNA sequencing (scRNA-seq)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32669324
DOI: 10.1681/ASN.2020030326
PMCID: PMC7461682

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