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Article

Senataxin mediates R-loop resolution on HPV episomes

24 Jul 2024

Abstract excerpt

Three-stranded DNA-RNA structures known as R-loops that form during papillomavirus transcription can cause transcription-replication conflicts and lead to DNA damage. We found that R-loops accumulated at the viral early promoter in human papillomavirus (HPV) episomal cells but were greatly reduced in cells with integrated HPV genomes. RNA-DNA helicases unwind R-loops and allow for transcription and replication to...

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PMID: 39046232
DOI: 10.1128/jvi.01003-24

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