Article
Breaking the DNA damage response to improve cervical cancer treatment.
Cancer treatment reviews - 1 Jan 2016
Wieringa Hylke W, van der Zee Ate G J, de Vries Elisabeth G E, van Vugt Marcel A T M
Abstract excerpt
Every year, cervical cancer affects ∼500,000 women worldwide, and ∼275,000 patients die of this disease. The addition of platin-based chemotherapy to primary radiotherapy has increased 5-year survival of advanced-stage cervical cancer patients, which is, however, still only 66%. One of the factors thought to contribute to treatment failure is the ability of tumor cells to repair chemoradiotherapy-induced DNA...
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