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The DNA damage response network in the treatment of head and neck squamous cell carcinoma

11 Mar 2021

Abstract excerpt

BACKGROUND: We sought to determine whether DNA damage response (DDR)-related aberrations predict therapeutic benefit in cisplatin-treated head and neck squamous cell carcinoma (HNSCC) patients and how DDR pathways are modulated after treatment with olaparib alone or in combination with cisplatin or durvalumab. PATIENTS AND METHODS: Oxidative stress, abasic sites and DDR-related parameters, including endogenous...

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PMID: 33714009
DOI: 10.1016/j.esmoop.2021.100075

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