Article

CYP4F2 is a human-specific determinant of circulating N-acyl amino acid levels

2023-03-09

Abstract excerpt

N-acyl amino acids are a large family of circulating lipid metabolites that modulate energy expenditure and fat mass in rodents. However, little is known about the regulation and potential cardiometabolic functions of N-acyl amino acids in humans. Here, we analyze the cardiometabolic phenotype associations and genetic regulation of four plasma N-fatty acyl amino acids (N-oleoyl-leucine, N-oleoyl-phenylalanine, N-o...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8f8ee724-0635-5418-b983-2eee39832c1a
DOI: 10.1101/2023.03.09.531581

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

CYP4F2 is a human-specific determinant of circulating N-acyl amino acid levelsDOI 10.1101/2023.03.09.531581Read

Novel genetic insights into the roles of amino acids in metabolic dysfunction-associated steatotic liver diseaseSemantic proximity Read

Novel genetic insights into the roles of amino acids in metabolic dysfunction-associated steatotic liver diseaseSemantic proximity Read

Dietary isoleucine content defines the metabolic and molecular response to a Western dietSemantic proximity Read

Genetic regulation of fatty acid content in adipose tissue.Semantic proximity Read

Genetic Variation of Human Long-Chain Fatty Acyl-CoA Synthetase and Nutritional Implication.Semantic proximity Read

Ancestry-driven metabolite variation provides insights into disease states in admixed populations.Semantic proximity Read

Reciprocal adipose-heart regulation of NRACSemantic proximity Read

Genetic architecture of the murine serum metabolome reveals carboxyl esterases as master regulators of circulating fatty acid metabolismSemantic proximity Read

The Metabolite Profiles of the Obese Population Are Gender-DependentSemantic proximity Read

Genetic Regulation of Plasma Lipid Species and Their Association with Metabolic PhenotypesSemantic proximity Read

Integration of Genome-Wide SNP Data and Gene-Expression Profiles Reveals Six Novel Loci and Regulatory Mechanisms for Amino Acids and Acylcarnitines in Whole Blood.Semantic proximity Read

Genetic variation in lipid desaturases and its impact on the development of human disease.Semantic proximity Read