Article

Regulatory risk loci link disrupted androgen response to pathophysiology of Polycystic Ovary Syndrome

2025-03-27

Abstract excerpt

A major challenge in deciphering the complex genetic landscape of Polycystic Ovary Syndrome (PCOS) lies in the limited understanding of how susceptibility loci drive molecular mechanisms across diverse phenotypes. To address this, we integrated molecular and epigenomic annotations from proposed causal cell-types and employed a deep learning (DL) framework to predict cell-type-specific regulatory effects of PCOS ri...

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Literature Corpus work: 8f82e2d1-2394-5853-bb63-8151e2864b08
DOI: 10.1101/2025.03.26.25324630

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