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Article

Functional genomics of PCOS: from GWAS to molecular mechanisms.

Trends in endocrinology and metabolism: TEM - 1 Mar 2015

McAllister Jan M, Legro Richard S, Modi Bhavi P, Strauss Jerome F

Abstract excerpt

Polycystic ovary syndrome (PCOS) is a common endocrinopathy characterized by increased ovarian androgen biosynthesis, anovulation, and infertility. PCOS has a strong heritable component based on familial clustering and twin studies. Genome-wide association studies (GWAS) identified several PCOS candidate loci including LHCGR, FSHR, ZNF217, YAP1, INSR, RAB5B, and C9orf3. We review the functional roles of strong...

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Source

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Identifiers

PMID: 25600292
DOI: 10.1016/j.tem.2014.12.004
PMCID: PMC4346470

Genes

INSR
LHCGR
FSHR
YAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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