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Article

Phenotype and Tissue Expression as a Function of Genetic Risk in Polycystic Ovary Syndrome.

PloS one - 1 Jan 2017

Pau Cindy T, Mosbruger Tim, Saxena Richa, Welt Corrine K

Abstract excerpt

Genome-wide association studies and replication analyses have identified (n = 5) or replicated (n = 10) DNA variants associated with risk for polycystic ovary syndrome (PCOS) in European women. However, the causal gene and underlying mechanism for PCOS risk at these loci have not been determined. We hypothesized that analysis of phenotype, gene expression and metformin response as a function of genotype would...

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Identifiers

PMID: 28068351
DOI: 10.1371/journal.pone.0168870
PMCID: PMC5221814

Genes

GATA4
KRR1
FSHB
BLK
ERBB4
GLIPR1
NEIL2
PHLDA1
TOX3

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