Article
Mitochondrial Transplantation Attenuates Brain Dysfunction in Sepsis by Driving Microglial M2 Polarization.
Molecular neurobiology - 1 Sept 2020
Yan Chaoying, Ma Zhi, Ma Hongli, Li Qing, Zhai Qian, Jiang Tao, Zhang Zhanqin, Wang Qiang
Abstract excerpt
Activation of microglia and mitochondrial dysfunction are two major contributors to the pathogenesis of sepsis-associated brain dysfunction. Mitochondrial dysfunction can alter the immunological profile of microglia favoring to a pro-inflammatory phenotype. Mitochondrial transplantation, as an emerging mitochondria-targeted therapy, possesses considerable therapeutic potential in various central nervous system...
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