Article

Global screening and genetic engineering of Tistrella enable sustainable production of didemnin drugs

2023-05-04

Abstract excerpt

<title>Abstract</title> <p>The <italic>Tistrella</italic> genus can produce the cyclic depsipeptide didemnin B, but the biosynthetic origin of its analogue, plitidepsin, remains unknown. Plitidepsin is an approved anticancer drug and an anti-COVID-19 agent in phase III clinical trials. Here, we employed a novel approach that combined microbial and chemical synthesis to produce plitidepsin. We first investigated t...

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Literature Corpus work: 8f3b931c-9867-5792-817e-9d77b086f19e
DOI: 10.21203/rs.3.rs-2879035/v1

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