Article

Growth Hormone-Releasing Hormone (GHRH) Antagonist Peptides Combined with PI3K Isoform Inhibitors Enhances Cell Death in Prostate Cancer

2025-03-19

Abstract excerpt

Antagonists of GHRH have experimental therapeutic value but as single agents are not likely to improve clinical outcomes, especially in advanced prostate cancer resistant to androgen deprivation therapy. Our objective is to identify anti-cancer drugs that in combination with MIA-602 or -690 GHRH antagonists increase cell death in all types of prostate cancer. We identified inhibitors of PI3Ka or PI3Kb that consist...

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Literature Corpus work: 8f30fe0a-29e0-5524-bfb6-4d8e77a74d52
DOI: 10.20944/preprints202503.1386.v1

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