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The Role of Serotonin (5-Hydroxytryptamine <sub>1A</sub> and <sub>1B</sub> ) Receptors in Prostate Cancer Cell Proliferation

4 Sept 2006

Abstract excerpt

PURPOSE: Serotonin (5-hydroxytryptamine), a monoamine neurotransmitter released by prostate neuroendocrine cells, has a fundamental role in tumor growth, differentiation and gene expression. We investigated the effect of 5-hydroxytryptamine and 5-hydroxytryptamine antagonists on the growth of prostate cancer cells and we identified 5-hydroxytryptamine receptor expression in PC3 cells and in human hormone...

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Identifiers

PMID: 16952708
DOI: 10.1016/j.juro.2006.06.087

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