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Article

Tumor-associated macrophage-specific SERPING1 contributes to M1-phenotype transition and suppress colorectal cancer tumorigenesis via NF-κB pathway.

International journal of biological macromolecules - 1 Jan 2026

Wei Hao-Tang, Luo Xiao-Ling, Lv Feng, Deng Hao-Wei, Tang Li-Ping, Li Ke-Zhi, Xie Li-Ye, Ning Shu-Fang, Jiang Hai-Xing, Hu Bang-Li

Abstract excerpt

Macrophages play a complex role in pathogenesis and progression of colorectal cancer (CRC), but the underlying mechanism remained need to be elucidated. In this study, we observed that, the proportion of macrophage was increased in CRC tissues by analyzing scRNA-seq datasets. Analysis from CRC datasets confirmed that the proportion of M0 and M1 was increased, and M2 was decreased in tumor tissues compared with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41513188
DOI: 10.1016/j.ijbiomac.2026.150144

Genes

SERPING1

Provenance

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