Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of SPP1+ macrophages as an immune suppressor in hepatocellular carcinoma using single-cell and bulk transcriptomics

3 Dec 2024

Abstract excerpt

Introduction Macrophages and T cells play crucial roles in liver physiology, but their functional diversity in hepatocellular carcinoma (HCC) remains largely unknown. Methods Two bulk RNA-sequencing (RNA-seq) cohorts for HCC were analyzed using gene co-expression network analysis. Key gene modules and networks were mapped to single-cell RNA-sequencing (scRNA-seq) data of HCC. Cell type fraction of bulk RNA-seq...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ferroptosis and cancer prognosis
Share to Immune cells in cancer
Share to Single-cell and spatial transcriptomics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39691723
DOI: 10.3389/fimmu.2024.1446453

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of SPP1+ macrophages as an immune suppressor in hepatocellular carcinoma using single-cell and bulk transcriptomicsPMID 39691723Read ↗

Construction of TME and Identification of crosstalk between malignant cells and macrophages by SPP1 in hepatocellular carcinoma.Semantic proximity Read ↗

SPP1+ tumor-associated macrophages define a high-risk subgroup and inform personalized therapy in hepatocellular carcinomaSemantic proximity Read ↗

M2-like tumor-associated macrophage-related biomarkers to construct a novel prognostic signature, reveal the immune landscape, and screen drugs in hepatocellular carcinomaSemantic proximity Read ↗

Bulk and single‐cell transcriptome reveal the immuno‐prognostic subtypes and tumour microenvironment heterogeneity in HCCSemantic proximity Read ↗

Integrated single-cell and bulk RNA sequencing reveals immune-related SPP1+ macrophages as a potential strategy for predicting the prognosis and treatment of liver fibrosis and hepatocellular carcinomaSemantic proximity Read ↗

Multi-Omics Deciphering of the Characteristics, Functional Mechanisms, and Prognostic Value of Tumor-Associated Macrophage Subsets in Hepatocellular CarcinomaSemantic proximity Read ↗

SPP1+ macrophages: A malignant macrophage subset in the colorectal cancer microenvironment revealed by single-cell sequencingSemantic proximity Read ↗

Global immune characterization of HBV/HCV-related hepatocellular carcinoma identifies macrophage and T-cell subsets associated with disease progressionSemantic proximity Read ↗

A novel prognostic model based on single-cell RNA sequencing data for hepatocellular carcinomaSemantic proximity Read ↗

Integrated single-cell and bulk RNA sequencing analysis revealing the role of FCGR2A on prognosis and immune infiltration of hepatocellular carcinomaSemantic proximity Read ↗

Single-cell transcriptome analysis reveals the key genes associated with macrophage polarization in liver cancerSemantic proximity Read ↗

Systematic analysis and experimental validation of the prognostic and immunological effects of SPP1 tumor-associated macrophage features in colorectal cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.