Article

A guanosine metabolism-bioenergetics intersection drives Parkinson’s disease

2026-08-04

Abstract excerpt

Several Parkinson’s Disease (PD) linked mutations are known to drive deficits in a pathway that relies on an adequate supply of guanosine nucleotide triphosphate (GTP) to drive cellular neuronal processes. Similarly, there is strong evidence that a deficit in bioenergetic support for neuron function is also a major genetic driver of PD. We show here that the reliance on these two purine-based metabolites intersect...

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Literature Corpus work: 69efc6fd-d99a-5336-80fb-7547df8df113
DOI: 10.64898/2026.07.29.741503

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