Article

Tamoxifen reduces mitochondrial respiration, oncogenic signaling and mutant allele burden in a myeloproliferative neoplasm subset

2023-03-30

Abstract excerpt

<title>Abstract</title> <p>Current therapies for myeloproliferative neoplasms (MPN) improve symptoms but have limited effect on tumor size. In preclinical studies, tamoxifen restored normal apoptosis in mutated hematopoietic stem and progenitor cells (HSPCs). TAMARIN is a Phase-II, multicenter, single-arm clinical trial assessing tamoxifen’s safety and activity in patients with stable MPNs, no prior thrombotic ev...

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Literature Corpus work: 523cae62-47e0-5d3f-a7f2-18d47f9d82ce
DOI: 10.21203/rs.3.rs-2687765/v1

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