Article

Heterozygous deletion of SYNGAP enzymatic domains in rats causes selective learning, social and seizure phenotypes

2020-10-14

Abstract excerpt

Pathogenic variants in SYNGAP1 are one of the most common genetic causes of nonsyndromic intellectual disability (ID) and are considered a risk for autism spectrum disorder (ASD). SYNGAP1 encodes a syn aptic G TPase a ctivating p rotein that modulates the intrinsic GTPase activity of several small G-proteins and is implicated in regulating the composition of the postsynaptic density. By targeting the deletio...

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Literature Corpus work: bff6e909-c529-5eea-b08d-09e245380ae7
DOI: 10.1101/2020.10.14.339192

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