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Hallmarks and Molecular Tools for the Study of Mitophagy in Parkinson’s Disease

2 Jul 2022

Abstract excerpt

The best-known hallmarks of Parkinson's disease (PD) are the motor deficits that result from the degeneration of dopaminergic neurons in the substantia nigra. Dopaminergic neurons are thought to be particularly susceptible to mitochondrial dysfunction. As such, for their survival, they rely on the elaborate quality control mechanisms that have evolved in mammalian cells to monitor mitochondrial function and...

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PMID: 35805181
DOI: 10.3390/cells11132097

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