Article

Multivariate variance components analysis uncovers genetic architecture of brain isoform expression and novel psychiatric disease mechanisms

2022-10-21

Abstract excerpt

Multivariate variance components linear mixed models are fundamental statistical models in quantitative genetics, widely used to quantify SNP-based heritability ( h 2 SNP ) and genetic correlation ( r g ) across complex traits. However, maximum likelihood estimation of multivariate variance components models remains numerically challenging when the number of traits and variance components are both greater than two...

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Literature Corpus work: 66c5c8da-2b2e-5af5-ad50-e1a96aa7cb99
DOI: 10.1101/2022.10.18.22281204

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