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Article

The effects of myocilin expression on functionally relevant trabecular meshwork genes: a mini-review.

Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics - 1 Jan 2000

Borrás Teresa

Abstract excerpt

Myocilin is a secreted glaucoma-associated protein, specifically induced by dexamethasone in human trabecular meshwork cells, where it was discovered. Myocilin is expressed in several tissues of the body, but it causes disease only in the eye. The protein contains two domains: an N-terminal region with significant homologies to nonmuscle myosin, and a C-terminal region, which is similar to the olfactomedin...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24564495
DOI: 10.1089/jop.2013.0218
PMCID: PMC3991974

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Related research

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Research trail→

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The effects of myocilin expression on functionally relevant trabecular meshwork genes: a mini-review.PMID 24564495Read ↗

Keeping an Eye on Myocilin: A Complex Molecule Associated with Primary Open-Angle Glaucoma SusceptibilitySemantic proximity Read ↗

[The role of myocilin in the pathogenesis of primary open-angle glaucoma].Semantic proximity Read ↗

Cystatin a, a potential common link for mutant myocilin causative glaucoma.Semantic proximity Read ↗

Serine to proline mutation at position 341 of MYOC impairs trabecular meshwork function by causing autophagy deregulationSemantic proximity Read ↗

Gene expression profile in human trabecular meshwork from patients with primary open-angle glaucoma.Semantic proximity Read ↗

Glaucoma-associated myocilin: a better understanding but much more to learn.Semantic proximity Read ↗

Serine to proline mutation at position 341 of MYOC impairs trabecular meshwork function by causing autophagy deregulationSemantic proximity Read ↗

CRISPR-Cas9–based treatment of myocilin-associated glaucomaSemantic proximity Read ↗

The glaucoma-associated olfactomedin domain of myocilin is a novel calcium binding protein.Semantic proximity Read ↗

The identification of myocilin-associated proteins in the human trabecular meshwork.Semantic proximity Read ↗

First look at the effect of overexpression of TIGR/MYOC on the transcriptome of the human trabecular meshwork.Semantic proximity Read ↗

Accumulation of Asn450Tyr mutant myocilin in ER promotes apoptosis of human trabecular meshwork cells.Semantic proximity Read ↗

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