Article

Telomere maintaining germline and somatic variants in thyroid cancer and melanoma

2026-05-25

Abstract excerpt

<h4>Importance</h4> Non-medullary thyroid cancer (NMTC) and melanoma are associated with inherited long telomeres due to germline pathogenic/likely pathogenic variants (PV/LPV) in POT1 , TINF2 , and ACD resulting in long-telomere syndrome (LTS) and they commonly have somatic TERT promoter mutations. The genetic relationship between these variants and their clinical associations are defined incompletely and ma...

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Literature Corpus work: b050e46c-e1f9-5990-9d10-0ba127430189
DOI: 10.64898/2026.05.22.26353814

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