Article

Generation and validation of transmitochondrial cybrid and platelet models to investigate the effect of mitochondrial genotype upon drug-induced liver injury

2019-01-01

Abstract excerpt

Idiosyncratic drug-induced liver injury (DILI) is a major concern for patient health and the pharmaceutical industry. Idiosyncratic DILI is characterised by a complex dose-response relationship, lack of predictivity from the primary pharmacology of a drug and significant interindividual variability, all of which contribute towards the limited preclinical prediction of these reactions. Drug-induced mitochondrial dy...

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Literature Corpus work: 8e65aa8a-e108-5e47-ab93-821976bbf6e7
DOI: 10.17638/03036246

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