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Article

Assessment of the impact of mitochondrial genotype upon drug-induced mitochondrial dysfunction in platelets derived from healthy volunteers.

Archives of toxicology - 1 Apr 2021

Ball Amy L, Bloch Katarzyna M, Rainbow Lucille, Liu Xuan, Kenny John, Lyon Jonathan J, Gregory Richard, Alfirevic Ana, Chadwick Amy E

Abstract excerpt

Mitochondrial DNA (mtDNA) is highly polymorphic and encodes 13 proteins which are critical to the production of ATP via oxidative phosphorylation. As mtDNA is maternally inherited and undergoes negligible recombination, acquired mutations have subdivided the human population into several discrete haplogroups. Mitochondrial haplogroup has been found to significantly alter mitochondrial function and impact...

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Identifiers

PMID: 33585966
DOI: 10.1007/s00204-021-02988-3
PMCID: PMC8032628

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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