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Article

The generation of HepG2 transmitochondrial cybrids to reveal the role of mitochondrial genotype in idiosyncratic drug-induced liver injury.

eLife - 6 Jun 2023

Ball Amy Louise, Jolly Carol E, Lennon Mark G, Lyon Jonathan J, Alfirevic Ana, Chadwick Amy E

Abstract excerpt

Background: Evidence supports an important link between mitochondrial DNA (mtDNA) variation and adverse drug reactions such as idiosyncratic drug-induced liver injury (iDILI). Here, we describe the generation of HepG2-derived transmitochondrial cybrids, to investigate the impact of mtDNA variation on mitochondrial (dys)function and susceptibility to iDILI. This study created 10 cybrid cell lines, each containing...

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Identifiers

PMID: 37278519
DOI: 10.7554/eLife.78187
PMCID: PMC10270688

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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