Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Investigating the importance of individual mitochondrial genotype in susceptibility to drug-induced toxicity.

Biochemical Society transactions - 30 Jun 2020

Penman Sophie L, Carter Alice S, Chadwick Amy E

Abstract excerpt

The mitochondrion is an essential organelle responsible for generating cellular energy. Additionally, mitochondria are a source of inter-individual variation as they contain their own genome. Evidence has revealed that mitochondrial DNA (mtDNA) variation can confer differences in mitochondrial function and importantly, these differences may be a factor underlying the idiosyncrasies associated with unpredictable...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Bacterial Agents
Share to Anti-Retroviral Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Antineoplastic Agents

Share to Cell Nucleus

Share to DNA, Mitochondrial

Share to Drug Development

Share to Drug-Related Side Effects and Adverse Reactions

Share to Mitochondria

Source

Open in PubMed Open full text

Identifiers

PMID: 32453388
DOI: 10.1042/BST20190233
PMCID: PMC7329340

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Investigating the importance of individual mitochondrial genotype in susceptibility to drug-induced toxicity.PMID 32453388Read ↗

Assessment of the impact of mitochondrial genotype upon drug-induced mitochondrial dysfunction in platelets derived from healthy volunteers.Semantic proximity Read ↗

Generation and validation of transmitochondrial cybrid and platelet models to investigate the effect of mitochondrial genotype upon drug-induced liver injurySemantic proximity Read ↗

The generation of HepG2 transmitochondrial cybrids to reveal the role of mitochondrial genotype in idiosyncratic drug-induced liver injury.Semantic proximity Read ↗

A Klinefelter patient with an additional mitochondrial mutation: Implications for genotype-driven treatment and mitochondrial mutational load in different tissues and family members.Semantic proximity Read ↗

The combination of nuclear and mitochondrial mutations as a risk factor for idiosyncratic toxicity.Semantic proximity Read ↗

Mitochondrial bioenergetics and drug-induced toxicity in a panel of mouse embryonic fibroblasts with mitochondrial DNA single nucleotide polymorphisms.Semantic proximity Read ↗

Influence of Mitochondrial Genetics on the Mitochondrial Toxicity of Linezolid in Blood Cells and Skin Nerve Fibers.Semantic proximity Read ↗

Mitochondrial toxicity and HIV therapySemantic proximity Read ↗

Next Generation Sequencing-Based Mitochondrial Genome Analysis In Relation To The Drug- Induced Toxicity In Korean SubjectsSemantic proximity Read ↗

Mitotoxic effects of the melanin-concentrating hormone receptor 1 (MCHr1) antagonist AZD1979 are influenced by mitochondrial DNA variation in HepG2 cybrids.Semantic proximity Read ↗

Unmasking the causes of multifactorial disorders: OXPHOS differences between mitochondrial haplogroups.Semantic proximity Read ↗

Long term adverse effects related to nucleoside reverse transcriptase inhibitors: Clinical impact of mitochondrial toxicitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.