Article

Transcriptome analysis of the NR1H3 mouse model of multiple sclerosis reveals a pro-inflammatory phenotype with dysregulation of lipid metabolism and immune response genes

2021-03-17

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> The development of effective treatments for multiple sclerosis (MS), and in particular its progressive forms, is hampered by the lack of etiologically relevant cellular and animal models of human disease. Models that recapitulate the biological and pathological processes leading to the onset and progression of MS in patients are likely to afford better translational efficacy...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 187a2c58-4cdd-56fe-ad7e-6cd8aaab97df
DOI: 10.1101/2021.03.17.435678

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Transcriptome analysis of the NR1H3 mouse model of multiple sclerosis reveals a pro-inflammatory phenotype with dysregulation of lipid metabolism and immune response genesDOI 10.1101/2021.03.17.435678Read

Characterisation of Transcriptional Changes in the Spinal Cord of the Progressive Experimental Autoimmune Encephalomyelitis Biozzi ABH Mouse Model by RNA Sequencing.Semantic proximity Read

A comparative transcriptomic analysis of mouse demyelination models and Multiple Sclerosis lesionsSemantic proximity Read

Natural genetic variation profoundly regulates gene expression in immune cells and dictates susceptibility to CNS autoimmunity.Semantic proximity Read

A Deep Transcriptome Meta-Analysis Reveals Sex-based Molecular Differences in Multiple SclerosisSemantic proximity Read

Gene expression and alternative splicing analysis in a large-scale Multiple Sclerosis studySemantic proximity Read

Transcriptome analysis of the adipose tissue in a mouse model of metabolic syndrome identifies gene signatures related to disease pathogenesisSemantic proximity Read

Genome-wide transcriptome architecture in a mouse model of Gulf War IllnessSemantic proximity Read

Gene Expression and Alternative Splicing Analysis in a Large-Scale Multiple Sclerosis Study.Semantic proximity Read

Investigating MS with MS: MALDI-TOF mass spectrometry imaging of sulfatide lipid expression in mouse cerebral tissue during CNS neuroinflammationSemantic proximity Read

A novel mouse model of cerebral adrenoleukodystrophy highlights NLRP3 activity in lesion pathogenesisSemantic proximity Read

Immune-responsive gene-1: The mitochondrial Key to Th17 Cell Pathogenicity in CNS AutoimmunitySemantic proximity Read

A Deep Transcriptome Meta-Analysis Reveals Sex Differences in Multiple SclerosisSemantic proximity Read