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ARID1 Proteins: from Transcriptional and Post-Translational Regulation to Carcinogenesis and Potential Therapeutics

23 Apr 2021

Abstract excerpt

The ARID1 proteins are mutually exclusive subunits of the BRG1/BRM-associated factor (BAF) complexes that play an important role in chromatin remodeling and regulate many fundamental cell functions. The role of ARID1s is well defined as a tumor-suppressive. The cancer cells evolve different mechanisms to downregulate ARID1s and inactivate their functions. ARID1s are frequently mutated in human cancer. The recent...

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PMID: 33890484
DOI: 10.2217/epi-2020-0414

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