Article

Clinically-weighted transcriptomic signatures for protein kinase inhibitor associated cardiotoxicity

2016-09-19

Abstract excerpt

<h4>ABSTRACT</h4> Cardiotoxicity (CT) involving diminished cardiac contractility and heart failure is a major adverse event associated with otherwise efficacious protein kinase inhibitors (KIs). Here, we sought to develop clinically-weighted transcriptomic signatures to predict risk of CT and to better understand the biological processes associated with CT risk. We obtained transcriptome-wide response profiles in...

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Literature Corpus work: 8db10f99-6dbb-5d60-b31b-3cebba5d387a
DOI: 10.1101/075754

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