Kinome profiling allows examination and prediction of kinase inhibitor cardiotoxicity

Abstract excerpt

<h4>Background</h4> Despite improved cancer outcomes with kinase inhibitors (KIs), their cardiotoxicity remains a significant clinical challenge. Current approaches to predict and prevent KI-induced cardiac adverse events (CAEs) are limited by an incomplete understanding of underlying mechanisms, including the contribution of off-target kinase engagement. <h4>Objectives</h4> To establish links between kinase inh...

Topics

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• CAR-T cell therapy research
• Cardiac electrophysiology and arrhythmias
• Chemotherapy-induced cardiotoxicity and mitigation
• Computational Drug Discovery Methods
• Lung Cancer Treatments and Mutations
• Melanoma and MAPK Pathways
• Pluripotent Stem Cells Research

Identifiers and source

Literature Corpus work

214e2c6e-a588-529a-abcf-599eb369abf3

DOI

10.64898/2026.04.03.716310