Article

predicTox: An integrated database of clinical risk frequencies and human gene expression signatures for cardiotoxic drugs

2025-05-24

Abstract excerpt

We have used drug-induced transcriptomic responses and whole-genome sequences in healthy human induced pluripotent stem cells (iPSC)-derived cardiomyocyte lines to identify cellular functional pathways and genomic variants potentially associated with the cardiotoxic effects of tyrosine kinase inhibitors (TKIs) and other cancer drugs. Here, we describe predicTox.org, an interactive website that organizes our data a...

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Literature Corpus work: d3f046b8-32b7-5cb4-9ae1-867cc516476f
DOI: 10.1101/2025.05.23.655401

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