Article

Decoding Non-coding SNPs: Systems Genomics Modelling Dissects the Heterogeneity of IBD

2024-10-30

Abstract excerpt

Genome-wide association studies have pinpointed numerous susceptibility loci in complex diseases like chronic immune-mediated inflammatory disorders (IMIDs), yet their impact on pathomechanisms remain poorly understood. Genetic epistasis, low effect sizes, and predominance within non-coding genomic regions, remain major challenges to the functional interpretation of IMID-associated single nucleotide polymorphisms...

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Literature Corpus work: 8d93934c-636f-59f8-b514-bcacf7582496
DOI: 10.1101/2024.10.28.24316194

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