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Developmental Theory of Aging Revisited: Focus on Causal and Mechanistic Links Between Development and Senescence

18 Jul 2011

Abstract excerpt

Senescence violates the most basic tenet of natural selection by causing death rather than individual survival. Thus, current theories favor the concept of antagonistic pleiotropy (AP) to explain how aging emerged in metazoans. Presumably, pleiotropic genes reduce vigor and limit longevity in adults. However, they also promote fitness and reproduction in juveniles, causing them to be selected and retained in the...

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PMID: 21767161
DOI: 10.1089/rej.2011.1162

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