Article

DNA methylation profiling in Huntington’s disease reveals disease associated changes in the striatum

2025-07-08

Abstract excerpt

<title>Abstract</title> <p> <bold>Background</bold> Huntington’s disease is caused by a trinucleotide CAG repeat expansion in the <italic>HTT</italic> gene. Despite displaying autosomal dominance, phenotypic variation exists amongst mutation carriers, in particular relating to the age that symptoms first occur. This variation is in part driven by an inverse relationship between CAG expansion size and age of s...

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Literature Corpus work: 8d372399-1c39-567c-b028-c1bfe8a048ae
DOI: 10.21203/rs.3.rs-6682049/v1

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