Back to search

Article

Epigenetic insights into neuropsychiatric and cognitive symptoms in Parkinson’s disease: A DNA co-methylation network analysis

2023-07-23

Abstract excerpt

Parkinson’s disease is a highly heterogeneous disorder, encompassing a complex spectrum of clinical presentation including motor, sleep, cognitive and neuropsychiatric symptoms. We aimed to investigate genome-wide DNA methylation networks in post-mortem Parkinson’s disease brain samples and test for region-specific association with common neuropsychiatric and cognitive symptoms. Of traits tested, we identify a co-...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
115477bb-8b04-551f-a968-f5fffbeef66c
DOI
10.1101/2023.07.20.549825
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Epigenetic insights into neuropsychiatric and cognitive symptoms in Parkinson’s disease: A DNA co-methylation network analysisDOI 10.1101/2023.07.20.549825
Epigenetic insights into neuropsychiatric and cognitive symptoms in Parkinson's disease: A DNA co-methylation network analysisSemantic proximity
DNA methylation patterns in the frontal lobe white matter of multiple system atrophy, Parkinson’s disease, and progressive supranuclear palsy: A cross-comparative investigationSemantic proximity
Neuron-Specific DNA Methylation Differences in the Prefrontal Cortex in Parkinson’s DiseaseSemantic proximity
White matter DNA methylation profiling reveals deregulation of HIP1, LMAN2, MOBP, and other loci in multiple system atrophySemantic proximity
Distinctive patterns of DNA methylation associated with Parkinson diseaseSemantic proximity
Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies.Semantic proximity
DNA methylation changes associated with Parkinson’s disease progression: outcomes from the first longitudinal genome-wide methylation analysis in bloodSemantic proximity
Cholinergic circuit genes in the healthy brain are differentially expressed in regions that exhibit gray matter loss in Parkinson’s diseaseSemantic proximity
Longitudinal Epigenome-Wide Methylation Study of Cognitive Decline and Motor Progression in Parkinson’s DiseaseSemantic proximity
A single-cell atlas of the human substantia nigra reveals cell-specific pathways associated with neurological disordersSemantic proximity
Parkinson’s Disease-Associated, Sex-specific Changes in DNA Methylation at <i>PARK7</i> (DJ-1), <i>ATXN1, SLC17A6, NR4A2</i> , and <i>PTPRN2</i> in Cortical NeuronsSemantic proximity
A Multimodal Single-Cell Epigenomic and 3D Genome Atlas of the Human Basal GangliaSemantic proximity
Select a neighboring publication to make it the new centre.