Article

A missense variant in <i>PAOX</i> in American Staffordshire Terriers with juvenile-onset polyneuropathy

2025-10-16

Abstract excerpt

Hereditary polyneuropathies in dogs mirror many features of human Charcot-Marie-Tooth (CMT) disease and offer valuable spontaneous models for discovery of genes’ variants involved in this disorder. A juvenile-onset polyneuropathy (JOP) in American Staffordshire Terriers (ASTs) resembles CMT, with motor and sensory deficits, often accompanied by laryngeal paralysis. To identify the underlying genetic cause, we cond...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8d2d4ef1-fe72-5d96-82c3-57c7e6684707
DOI: 10.1101/2025.10.16.682890

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A missense variant in <i>PAOX</i> in American Staffordshire Terriers with juvenile-onset polyneuropathyDOI 10.1101/2025.10.16.682890Read

A GJA9 frameshift variant is associated with polyneuropathy in Leonberger dogs.Semantic proximity Read

An ARHGEF10 deletion is highly associated with a juvenile-onset inherited polyneuropathy in Leonberger and Saint Bernard dogs.Semantic proximity Read

A CNTNAP1 Missense Variant Is Associated with Canine Laryngeal Paralysis and Polyneuropathy.Semantic proximity Read

Identification of a novel <i>CLPX</i> variant in a mixed breed dog with anemia and spinocerebellar ataxiaSemantic proximity Read

Association of spinocerebellar ataxia related variants with myokymia and neuromyotonia in dogsSemantic proximity Read

A SACS deletion variant in Great Pyrenees dogs causes autosomal recessive neuronal degenerationSemantic proximity Read

Identification of putative SNPs in progressive retinal atrophy affected Canis lupus familiaris using exome sequencing.Semantic proximity Read

Genome-wide association study for hereditary ataxia in the Parson Russell Terrier and DNA-testing for ataxia-associated mutations in the Parson and Jack Russell Terrier.Semantic proximity Read

A SACS deletion variant in Great Pyrenees dogs causes autosomal recessive neuronal degeneration.Semantic proximity Read

Progressive ataxia of Charolais cattle highlights a role of KIF1C in sustainable myelination.Semantic proximity Read

Genome-wide association analysis reveals a <i>SOD1</i> mutation in canine degenerative myelopathy that resembles amyotrophic lateral sclerosisSemantic proximity Read

A homozygous PIGN missense mutation in Soft-Coated Wheaten Terriers with a canine paroxysmal dyskinesia.Semantic proximity Read