Article

A SACS deletion variant in Great Pyrenees dogs causes autosomal recessive neuronal degeneration

2023-07-18

Abstract excerpt

ARSACS (autosomal recessive spastic ataxia of Charlevoix-Saguenay) is a human neurological disorder characterized by progressive cerebellar ataxia and peripheral neuropathy. A recently recognized disorder in Great Pyrenees dogs is similarly characterized by widespread central nervous system degeneration leading to progressive cerebellar ataxia and spasticity, combined with peripheral neuropathy. Onset of clinical...

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Literature Corpus work: b046d5ea-33bf-5a6d-ae0f-5894a249a9c3
DOI: 10.21203/rs.3.rs-3163989/v1

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