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Article

Spontaneous glutamate release is independent of calcium influx and tonically activated by the calcium-sensing receptor.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 23 Mar 2011

Vyleta Nicholas P, Smith Stephen M

Abstract excerpt

Spontaneous release of glutamate is important for maintaining synaptic strength and controlling spike timing in the brain. Mechanisms regulating spontaneous exocytosis remain poorly understood. Extracellular calcium concentration ([Ca(2+)](o)) regulates Ca(2+) entry through voltage-activated calcium channels (VACCs) and consequently is a pivotal determinant of action potential-evoked vesicle fusion. Extracellular...

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Identifiers

PMID: 21430159
DOI: 10.1523/JNEUROSCI.6398-10.2011
PMCID: PMC3097128

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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