Article

Stress-induced Rab11a-exosomes induce AREG-mediated cetuximab resistance in colorectal cancer

2023-12-20

Abstract excerpt

Exosomes are secreted vesicles made intracellularly in the endosomal system. We have previously shown that exosomes are not only made in late endosomes, but also in recycling endosomes marked by the monomeric G-protein Rab11a. These vesicles, termed Rab11a-exosomes, are preferentially secreted under nutrient stress from several cancer cell types, including HCT116 colorectal cancer (CRC) cells. HCT116 Rab11a-exosom...

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Literature Corpus work: 8d121b30-587f-5525-b218-21adcd441fb0
DOI: 10.1101/2023.12.19.572341

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