Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rab13 regulates sEV secretion in mutant KRAS colorectal cancer cells.

Scientific reports - 25 Sept 2020

Hinger Scott A, Abner Jessica J, Franklin Jeffrey L, Jeppesen Dennis K, Coffey Robert J, Patton James G

Abstract excerpt

Small extracellular vesicles (sEVs), 50-150 nm in diameter, have been proposed to mediate cell-cell communication with important implications in tumor microenvironment interactions, tumor growth, and metastasis. We previously showed that mutant KRAS colorectal cancer (CRC) cells release sEVs containing Rab13 protein and mRNA. Previous work had shown that disruption of intracellular Rab13 trafficking inhibits...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Communication
Share to Cell Movement
Share to Exosomes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Extracellular Vesicles

Share to Integrin beta1

Share to Proto-Oncogene Proteins p21(ras)

Share to rab GTP-Binding Proteins

Share to Tumor Microenvironment

Source

Open in PubMed Open full text

Identifiers

PMID: 32978434
DOI: 10.1038/s41598-020-72503-8
PMCID: PMC7519665

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rab13 regulates sEV secretion in mutant KRAS colorectal cancer cells.PMID 32978434Read ↗

Rab3 proteins and cancer: Exit strategiesSemantic proximity Read ↗

An Emerging Role of KRAS in Biogenesis, Cargo Sorting and Uptake of Cancer-Derived Extracellular VesiclesSemantic proximity Read ↗

An Ex(o)citing Machinery for Invasive Tumor GrowthSemantic proximity Read ↗

Small extracellular vesicles modulated by αVβ3 integrin induce neuroendocrine differentiation in recipient cancer cellsSemantic proximity Read ↗

RAB27B Drives a Cancer Stem Cell Phenotype in NSCLC Cells Through Enhanced Extracellular Vesicle Secretion.Semantic proximity Read ↗

Ral GTPases promote metastasis by controlling biogenesis and organ colonization of exosomesSemantic proximity Read ↗

The interrelated roles of RAB family proteins in the advancement of neoplastic growthSemantic proximity Read ↗

RAB27A promotes the proliferation and invasion of colorectal cancer cellsSemantic proximity Read ↗

Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.Semantic proximity Read ↗

RAB27A promotes melanoma cell invasion and metastasis via regulation of pro‐invasive exosomesSemantic proximity Read ↗

Extracellular RNA signatures of mutant KRAS(G12C) lung adenocarcinoma cellsSemantic proximity Read ↗

Rab13 Sustains Breast Cancer Stem Cells by Supporting Tumor–Stroma Cross-talkSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.