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Article

The epithelial polarity regulator LGALS9/galectin-9 induces fatal frustrated autophagy in KRAS mutant colon carcinoma that depends on elevated basal autophagic flux.

Autophagy - 1 Jan 2015

Wiersma Valerie R, de Bruyn Marco, Wei Yunwei, van Ginkel Robert J, Hirashima Mitsuomi, Niki Toshiro, Nishi Nozomu, Zhou Jin, Pouwels Simon D, Samplonius Douwe F, Nijman Hans W, Eggleton Paul, Helfrich Wijnand, Bremer Edwin

Abstract excerpt

Oncogenic mutation of KRAS (Kirsten rat sarcoma viral oncogene homolog) in colorectal cancer (CRC) confers resistance to both chemotherapy and EGFR (epidermal growth factor receptor)-targeted therapy. We uncovered that KRAS mutant (KRAS(mut)) CRC is uniquely sensitive to treatment with recombinant LGALS9/Galectin-9 (rLGALS9), a recently established regulator of epithelial polarity. Upon treatment of CRC cells,...

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Identifiers

PMID: 26086204
DOI: 10.1080/15548627.2015.1063767
PMCID: PMC4590647

Genes

KRAS
BRAF
LGALS9
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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