Article

Intracellular nanoparticle delivery by oncogenic KRAS-mediated macropinocytosis

2019-06-03

Abstract excerpt

The RAS family of oncogenes ( KRAS, HRAS, NRAS ) are the most frequent mutations in cancers and regulate key signaling pathways that drive tumor progression. As a result, drug delivery targeting RAS -driven tumors has been a long-standing challenge in cancer therapy. Mutant RAS activates cancer cells to actively take up nutrients, including glucose, lipids, and albumin, via macropinocytosis to fulfill their en...

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Literature Corpus work: 6099b3af-4a2e-5237-ab0c-c3c70c52ca5e
DOI: 10.1101/658039

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