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Article

KRAS mutation-driven enhanced macropinocytosis: using albumin as a trojan horse for delivering nanomedicine.

Nanomedicine (London, England) - 1 Jul 2025

Rathod Drishti, Vats Mukti, Gawali Poonam, Otagho Osaretin, Dholariya Bhoomi, Patel Ketan

Abstract excerpt

Kirsten Rat Sarcoma Virus Oncogene Homolog (KRAS), the most mutated oncogene, drives tumoral progression by leveraging macropinocytosis. This nutrient uptake pathway is responsible for promoting the relentless growth of KRAS-mutant tumoral cells while also unlocking a new frontier for the exploration of innovative therapeutic approaches. Leveraging KRAS-driven macropinocytosis, researchers are instigating...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40600426
DOI: 10.1080/17435889.2025.2524312
PMCID: PMC12239804

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

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Research trail→

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KRAS mutation-driven enhanced macropinocytosis: using albumin as a trojan horse for delivering nanomedicine.PMID 40600426Read ↗

Intracellular nanoparticle delivery by oncogenic KRAS-mediated macropinocytosisSemantic proximity Read ↗

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Gold Nanoparticles Inhibit Macropinocytosis by Decreasing KRAS Activation.Semantic proximity Read ↗

Therapeutically reprogrammed nutrient signalling enhances nanoparticulate albumin bound drug uptake and efficacy in KRAS-mutant cancer.Semantic proximity Read ↗

Survival strategies of cancer cells: the role of macropinocytosis in nutrient acquisition, metabolic reprogramming, and therapeutic targetingSemantic proximity Read ↗

Stimulating macropinocytosis of peptide-drug conjugates through DNA-dependent protein kinase inhibition for treating KRAS-mutant cancer.Semantic proximity Read ↗

The Dual Role of Macropinocytosis in Cancers: Promoting Growth and Inducing Methuosis to Participate in Anticancer Therapies as TargetsSemantic proximity Read ↗

RAS-Driven Macropinocytosis of Albumin or Dextran Reveals Mutation-Specific Target Engagement of RAS p.G12C Inhibitor ARS-1620 by NIR-Fluorescence Imaging.Semantic proximity Read ↗

An Emerging Role of KRAS in Biogenesis, Cargo Sorting and Uptake of Cancer-Derived Extracellular VesiclesSemantic proximity Read ↗

Dual blockade of macropinocytosis and asparagine bioavailability shows synergistic anti-tumor effects on KRAS-mutant colorectal cancer.Semantic proximity Read ↗

Novel selective inhibitors of macropinocytosis-dependent growth in pancreatic ductal carcinoma.Semantic proximity Read ↗

Catabolic pathways regulated by mTORC1 are pivotal for survival and growth of cancer cells expressing mutant Ras.Semantic proximity Read ↗

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