<scp>LDHA</scp> deficiency inhibits trophoblast proliferation via the <scp>PI3K</scp> / <scp>AKT</scp> / <scp>FOXO1</scp> / <scp>CyclinD1</scp> signaling pathway in unexplained recurrent spontaneous abortion

Abstract excerpt

Dysregulated trophoblast proliferation, invasion, and apoptosis may cause several pregnancy-associated complications, such as unexplained recurrent spontaneous abortion (URSA). Recent studies have shown that metabolic abnormalities, including glycolysis inhibition, may dysregulate trophoblast function, leading to URSA. However, the underlying mechanisms remain unclear. Herein, we found that lactate dehydrogenase...

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