Back to search

Article

Targeting endometrial cancer stem cell activity with metformin is inhibited by patient-derived adipocyte-secreted factors

2019-02-28

Abstract excerpt

<h4>Translational relevance</h4> Endometrial cancer stem cells are reported to drive metastasis and disease relapse and are resistant to commonly used chemotherapeutic drugs. Here, we characterise ALDH high and CD133 +ve endometrial cancer stem cells with differing levels of cancer stem cell activity and stem cell and epithelial-mesenchymal transition (EMT) gene expression. Their proportions and activity are re...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
5674e81c-ea22-518d-8df4-197bf786acd6
DOI
10.1101/562744
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Targeting endometrial cancer stem cell activity with metformin is inhibited by patient-derived adipocyte-secreted factorsDOI 10.1101/562744
Adiponectin influences the behavior of stem cells in hormone-resistant breast cancerSemantic proximity
Glycolysis-mTORC1 crosstalk drives rapid proliferation in patient-derived endometrial cancer spheroids with ALDH activitySemantic proximity
Aberrant expression of genes associated with stemness and cancer in endometria and endometrioma in a subset of women with endometriosisSemantic proximity
Genetic, epigenetic and stem cell alterations in endometriosis: new insights and potential therapeutic perspectivesSemantic proximity
Hormonal Regulation of Patient-Derived Endometrial Cancer Stem-like Cells Generated by Three-Dimensional CultureSemantic proximity
Targeting Aldehyde Dehydrogenases to Eliminate Cancer Stem Cells in Gynecologic MalignanciesSemantic proximity
Autologous cell therapy with CD133+ bone marrow-derived stem cells for Asherman Syndrome: a phase 1/2 trialSemantic proximity
Metformin regulates breast cancer stem cell ontogeny by transcriptional regulation of the epithelial-mesenchymal transition (EMT) status.Semantic proximity
The IVF-generated human embryonic microenvironment reverses progestin resistance in endometrial cancer cells by inducing cancer stem cell differentiationSemantic proximity
The inhibitory effect of salinomycin on the proliferation, migration and invasion of human endometrial cancer stem-like cellsSemantic proximity
Molecular signature of human endometrial stem/progenitor cells at the single cell levelSemantic proximity
N-cadherin identifies human endometrial epithelial progenitor cells by in vitro stem cell assaysSemantic proximity
Select a neighboring publication to make it the new centre.