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Article

A Different Facet of p53 Function: Regulation of Immunity and Inflammation During Tumor Development

18 Oct 2021

Abstract excerpt

As a key transcription factor, the evolutionarily conserved tumor suppressor p53 (encoded by TP 53) plays a central role in response to various cellular stresses. A variety of biological processes are regulated by p53 such as cell cycle arrest, apoptosis, senescence and metabolism. Besides these well-known roles of p53, accumulating evidence show that p53 also regulates innate immune and adaptive immune...

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PMID: 34733856
DOI: 10.3389/fcell.2021.762651

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