Improved sampling of genotypes and species reveals new insights on de novo gene history and regulatory origins.

Abstract excerpt

The evolution of genes de novo from ancestrally nongenic sequences may be a significant mechanism of gene origin. Many studies have focused on identifying de novo genes in distant evolutionary comparisons, which bias the sample of de novo genes toward older genes that have acquired important functions and have been retained and refined by selection. In this report, we focus on the earliest steps in de novo gene...

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