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Article

Conditional Creation and Rescue of Nipbl-Deficiency in Mice Reveals Multiple Determinants of Risk for Congenital Heart Defects.

PLoS biology - 1 Sept 2016

Santos Rosaysela, Kawauchi Shimako, Jacobs Russell E, Lopez-Burks Martha E, Choi Hojae, Wikenheiser Jamie, Hallgrimsson Benedikt, Jamniczky Heather A, Fraser Scott E, Lander Arthur D, Calof Anne L

Abstract excerpt

Elucidating the causes of congenital heart defects is made difficult by the complex morphogenesis of the mammalian heart, which takes place early in development, involves contributions from multiple germ layers, and is controlled by many genes. Here, we use a conditional/invertible genetic strategy to identify the cell lineage(s) responsible for the development of heart defects in a Nipbl-deficient mouse model of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27606604
DOI: 10.1371/journal.pbio.2000197
PMCID: PMC5016002

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