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Lysosome inhibition sensitizes pancreatic cancer to replication stress by aspartate depletion

20 Mar 2019

Abstract excerpt

Functional lysosomes mediate autophagy and macropinocytosis for nutrient acquisition. Pancreatic ductal adenocarcinoma (PDAC) tumors exhibit high basal lysosomal activity, and inhibition of lysosome function suppresses PDAC cell proliferation and tumor growth. However, the codependencies induced by lysosomal inhibition in PDAC have not been systematically explored. We performed a comprehensive pharmacological...

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PMID: 30894490
DOI: 10.1073/pnas.1812410116

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