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Article

MET-Oncogenic and JAK2-Inactivating Alterations Are Independent Factors That Affect Regulation of PD-L1 Expression in Lung Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Sept 2018

Saigi Maria, Alburquerque-Bejar Juan J, Mc Leer-Florin Anne, Pereira Carolina, Pros Eva, Romero Octavio A, Baixeras Nuria, Esteve-Codina Anna, Nadal Ernest, Brambilla Elisabeth, Sanchez-Cespedes Montse

Abstract excerpt

Purpose: The blockade of immune checkpoints such as PD-L1 and PD-1 is being exploited therapeutically in several types of malignancies. Here, we aimed to understand the contribution of the genetics of lung cancer to the ability of tumor cells to escape immunosurveillance checkpoints.Experimental Design: More than 150 primary non-small cell lung cancers, including pulmonary sarcomatoid carcinomas, were tested for...

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Topics

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Share to AMP-Activated Protein Kinase Kinases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Janus Kinase 2

Share to Lymphocytes, Tumor-Infiltrating

Share to Neuropilin-1

Share to Proto-Oncogene Proteins c-met

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Share to Vascular Endothelial Growth Factor A

Source

Identifiers

PMID: 29898990
DOI: 10.1158/1078-0432.CCR-18-0267

Genes

MET
JAK2
STK11
NRP1
SOCS1
VEGFA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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