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Article

B2M gene expression shapes the immune landscape of lung adenocarcinoma and determines the response to immunotherapy.

Immunology - 1 Nov 2021

Zhao Yu, Cao Yuejiao, Chen Yiqi, Wu Lei, Hang Hua, Jiang Chenxia, Zhou Xiaorong

Abstract excerpt

Loss of the B2M gene is associated with tumour immune escape and resistance to immunotherapy. However, genetic alterations of the B2M gene are rare. We performed an integrative analysis of the mutational and transcriptional profiles of large cohorts of non-small-cell lung cancer (NSCLC) patients and found that epigenetic downregulation of B2M is common. B2M-low tumours exhibit a suppressive immune...

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Identifiers

PMID: 34115389
DOI: 10.1111/imm.13384
PMCID: PMC8517590

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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